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An antihistamine is a drug that blocks the action of histamine—an allergy-causing chemical that’s released by certain cells in the body. ZYRTEC® begins to work at hour 1 on the first day you take it.

Antihistamines are used to treat runny nose, sneezing and other allergy symptoms. ZYRTEC® provides 24-hour relief, all day and all night. Since 2008, ZYRTEC® has been available over the counter, without a prescription. Today’s ZYRTEC® has the same exact strength as the version that required a prescription previously.

The 1-[(4-chlorophenylmethyl]-piperazine is alkylated with methyl (2-chloroethoxy)-acetate in the presence of sodium carbonate and xylene solvent to produce the Sn2 substitution product in 28% yield.

Saponification of the acetate ester is done by refluxing with potash in absolute ethanol to afford a 56% yield of the potassium salt intermediate.

Formerly prescription-only in many countries, cetirizine is now available without prescription in most countries.

Talk to your doctor if you have any questions, especially if you’re taking other medicines or being treated for any other conditions. (See next question.) Do NOT dispose of any ZYRTEC® product by emptying it into your sink, toilet or storm drain.In a 2005 study, the American College of Rheumatology conducted treatments initially using prednisone, followed by steroid dosages and azathioprine, omeprazole, and calcium and vitamin D supplements over the course of two years.The skin condition of the patient began to improve and the skin lesions lessened.This is then hydrolyzed with aqueous HCl and extracted to give an 81% yield of the carboxylic acid product.Cetirizine is marketed under the brand names Alatrol, Alerid, Alzene, Cetirin, Cetzine, Cezin, Histazine, Humex, Letizen, Reactine, Razene, Rigix, Triz, Zetop, Zirtec, Zirtek, Zodac, Zyllergy, Zynor, Zyrlek, and Zyrtec among others.Long-term daily usage of cetirizine may result in what resembles antihistamine dependency.No official study has been conducted to determine how long a patient may take cetirizine daily before expecting to encounter withdrawal symptoms when treatment stops.A column published in Psychopharmacology Today offers some advice.It turns out that the expiration date on a drug does stand for something, but probably not what you think it does.Since a law was passed in 1979, drug manufacturers are required to stamp an expiration date on their products.This is the date at which the manufacturer can still guarantee the full potency and safety of the drug.Like many other antihistamine medications, cetirizine is commonly prescribed in combination with pseudoephedrine, a decongestant.It is not recommended to take any medication after the expiration date and since Zyrtec is an allergy medication I would get a new one as soon as possible. This is a dilemma many people face in some way or another.Most of what is known about drug expiration dates comes from a study conducted by the Food and Drug Administration at the request of the military.With a large and expensive stockpile of drugs, the military faced tossing out and replacing its drugs every few years.

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